Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
권호 표지

Activation of C/EBP$\beta$ by PD98059 leads to the induction of GSTA2

  • Park, E-Y (National Research Laboratory, College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National Univ.) ;
  • Kang, K-W (National Research Laboratory, College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National Univ) ;
  • Kim, S-G (National Research Laboratory, College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National Univ.)
  • Published : 2003.05.01
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Abstract

Induction of glutathione S-transferases is associated with cancer chemoprevention. We reported that PD98059, an MKK1 inhibitor, induces glutathione Stransferase A2 (rGSTA2). This report comparatively examines the role of CCAAT/enhancer binding protein (C/EBP) and Nrf-2 in the induction of rGSTA2 by PD98059. PD98059 at the concentrations effective for the inhibition of MKKI increased the rGSTA2 protein and mRNA levels in H4IIE cells. (omitted)

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