Inhibitory effects of dihydrohinokiflavone on tumor cell growth and invasion

  • Yun, Chang-Hyun (Department of Biological Sciences, Korea Advanced Institute of Science and Technology) ;
  • Yoon, Sang-Oh (Department of Biological Sciences, Korea Advanced Institute of Science and Technolog) ;
  • Chung, An-Sik (Department of Biological Sciences, Korea Advanced Institute of Science and Technology)
  • Published : 2003.05.01

Abstract

Matrix metalloproteinases (MMPs) inhibitors were screened from Metasequoia glyptostroboides and one potent inhibitor, dihydrohinokiflavone (DHHF), a biflavonoid, was selected. DHHF inhibited proliferation of HT1080, human fibrosarcoma cells in a dose-dependent manner. Noncytotoxic levels of DHHF dramatically decreased MMP-9 and MMP-2 production in unistimulated cells, but did not change the level of tissue inhibited of metalloproteinase (TIMP)-1, an inhibitor of MMP-9.(omitted)

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