Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)
- 2003.05a
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- Pages.41-42
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- 2003
Inhibitory effects of dihydrohinokiflavone on tumor cell growth and invasion
- Yun, Chang-Hyun (Department of Biological Sciences, Korea Advanced Institute of Science and Technology) ;
- Yoon, Sang-Oh (Department of Biological Sciences, Korea Advanced Institute of Science and Technolog) ;
- Chung, An-Sik (Department of Biological Sciences, Korea Advanced Institute of Science and Technology)
- Published : 2003.05.01
Abstract
Matrix metalloproteinases (MMPs) inhibitors were screened from Metasequoia glyptostroboides and one potent inhibitor, dihydrohinokiflavone (DHHF), a biflavonoid, was selected. DHHF inhibited proliferation of HT1080, human fibrosarcoma cells in a dose-dependent manner. Noncytotoxic levels of DHHF dramatically decreased MMP-9 and MMP-2 production in unistimulated cells, but did not change the level of tissue inhibited of metalloproteinase (TIMP)-1, an inhibitor of MMP-9.(omitted)
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