Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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Strain-specific mammary tumor development following life-time oral administration of Ochratoxin A in DA and Lewis rats

  • Son, Woo-Chan (Department of Veteinary Public Health, College of Veterinary Medicine, Seoul National University) ;
  • Lee, Yong-Soon (Department of Veteinary Public Health, College of Veterinary Medicine, Seoul National University) ;
  • Kang, Kyung-Sun (Department of Veteinary Public Health, College of Veterinary Medicine, Seoul National University)
  • Published : 2003.05.01
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Abstract

Ochratoxin A (OA), a potent nephrotoxin in several species, is knownto be a renal carcinogen in animals and is implicated in the etiology of Balkan endemic nephropathy (BEN). The NTP (National Toxicology Program) classified Ochratoxin A as having clear evidence of carcinogenic activity, based on uncommon tubular adenomas and tubular cell carcinomas of the kidney and multiple fibroadenomas of the mammary gland, seen in the rat.(omitted)

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