Proceedings of the Korea Society of Environmental Toocicology Conference (한국환경독성학회:학술대회논문집)
- 2003.05a
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- Pages.177-177
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- 2003
Association study between vitamin D receptor gene polymorphism and chronic periodontitis in Koreans
- Kim, Seon-Jeong (Dept. of Life Science, Sahmyook University) ;
- Jang, Dai-Ho (Dept. of Life Science, Sahmyook University) ;
- Kang, Byung-Yong (Research Institute for Life Science, Sahmyook University) ;
- Kim, Hyun-Hee (Dept. of Life Science, Sahmyook University) ;
- Lee, Kang-Oh (Dept. of Life Science, Sahmyook University)
- Published : 2003.05.01
Abstract
Adult periodontitis is a chronic inflammatory disease whose etiology is not well defined. Recent studies have shown that vitamin D receptor gene has been a candidate for the susceptibility of adult periodontitis. The purpose of this study is to investigate the frequency of Taq I restriction fragment length polymorphism (RELP) in the vitamin D receptor gene in 141 periodontically healthy controls and 32 adult periodontitis patients. Taq I RFLP in the vitamin D receptor gene were detected by PCR amplification, followed by restriction enzyme digestion and 2% agarose gel electrophoresis. There were no significant difference in the distribution of Taq I RFLP between healthy controls and adult periodontitis group (P > 0.05). Thus, Taq I RFLP in the vitamin D receptor gene may not confer the susceptibility to adult periodontitis in Korean population. However, t allele distributions of this RFLP showed various frequencies among ethnic groups studied. Further studies in other ethnic groups will be required.