Proceedings of the Korea Society of Environmental Toocicology Conference (한국환경독성학회:학술대회논문집)
- 2003.05a
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- Pages.178-179
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- 2003
Changes of testosterone production in adult mouse testis and serum after wholebody irradiation
- Chun, Ki-Jung (Korea Atomic Energy Research Institute) ;
- Kim, Jihyang (Hanyang University, Dept. of Life Science) ;
- Kim, Woo-Jung (Korea Atomic Energy Research Institute) ;
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Kim, Jin-Kyu
(Korea Atomic Energy Research Institute) ;
- Kim, Bonghee (Chung Nam National University, College of Pharmacy) ;
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Yoon, Yong-Dal
(Hanyang University, Dept. of Life Science)
- Published : 2003.05.01
Abstract
The testis is composed of four cell types like supporting cells, steroid-producing cells, connective tissue cells and germ cells. Apoptosis is a common phenomenon during spormatogenesis. Apoptosis of germ cells can also be induced by exposure to radiation. Previous studies have shown that most types of germ cells are rather radiosensitive while somatic cells in testis are much more radio-resistant. The somatic cells in testis are divided to mainly Sertoli and Leydig cells. Though somatic cells are more radio-resistant than germ cells, radiation can induce the impairment of their function. This damaged function of somatic cells may accelerates degeneration of germ cell indirectly. Tn the present study, we have examined the apoptotic effect of mouse testis and irradiation effect of steroidogenesis of Leydig cells after irradiation.
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