Proceedings of the Korean Society of Developmental Biology Conference (한국발생생물학회:학술대회논문집)
- 2003.10a
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- Pages.101-101
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- 2003
Human Embryonic Stem Cells Co-Transfected with Tyrosine Hydroxylase and GTP Cyclohydrolase I Relieve Symptomatic Motor Behavior in a Rat Model of Parkinson′s Disease
- Kil, Kwang-Soo (Maria Infertility Hospital Medical Institute/Maria Biotech) ;
- Lee, Chang-Hyun (Maria Infertility Hospital Medical Institute/Maria Biotech) ;
- Shin, Hyun-Ah (Maria Infertility Hospital Medical Institute/Maria Biotech) ;
- Cho, Hwang-Yoon (Maria Infertility Hospital Medical Institute/Maria Biotech) ;
- Yoon, Ji-Yeon (Maria Infertility Hospital Medical Institute/Maria Biotech) ;
- Lee, Gun-Soup (Maria Infertility Hospital Medical Institute/Maria Biotech) ;
- Lee, Young-Jae (Maria Infertility Hospital Medical Institute/Maria Biotech) ;
- Kim, Eun-Young (Maria Infertility Hospital Medical Institute/Maria Biotech) ;
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Park, Se-Pill
(Maria Infertility Hospital Medical Institute/Maria Biotech)
- Published : 2003.10.01
Abstract
Main strategy for a treatment of Parkinson's disease (PD), due to a progressive degeneration of dopaminergic neurons, is a pharmaceutical supplement of dopamine derivatives or ceil replacement therapy. Both of these protocols have pros and cons; former exhibiting a dramatic relief but causing a severe side effects on long-term prescription and latter also having a proven effectiveness but having availability and ethical problems Embryonic stem (ES) cells have several characteristics suitable for this purpose. To investigate a possibility of using ES cells as a carrier of therapeutic gene(s), human ES (hES, MB03) cells were transfected with cDNAs coding for tyrosine hydroxylase (TH) in pcDNA3.1 (+) and the transfectants were selected using neomycin (250