Proceedings of the Korean Society of Applied Pharmacology (한국응용약물학회:학술대회논문집)
- 2003.04a
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- Pages.39-55
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- 2003
Anti-cancer Effects and Action Mechanism of Eurya emarginata
우묵사스레피의 항암효과 및 작용기전
Abstract
1. Extracts of the leaves of Eurya emarginata markedly inhibited the growth of leukemia cells such as HL-60, KG-1, U937, K562, and Jurkat. 2. When HL-60 cells were treated with the extract, DNA fragmentation, morphological changes and sub-G1 hypodiploid cells were observed. The expressions of c-myc mRNA were also dramatically decreased. 3. Cornoside and Eutigoside were isolated from the leaves of Eurya emarginata. 4. Eutigoside induced apoptosis through down-regulation of Bcl-2 expression and activation of caspases.
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