Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2002.10a
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- Pages.277.2-278
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- 2002
Examination of alginate/PEl/DNA polyplex as a gene delivery system: enhancing transfection efficiency in the presence of serum and reducing cytotoxicity
- Jiang, Ge (Korea Research Institute of Bioscience and Biotechnology) ;
- Min, Sang (Korea Research Institute of Bioscience and Biotechnolog) ;
- Kim, Mi-Na (Korea Research Institute of Bioscience and Biotechnolog) ;
- Lim, Mi-Jung (Korea Research Institute of Bioscience and Biotechnolog) ;
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Yeom, Young-Il
(Korea Research Institute of Bioscience and Biotechnology)
- Published : 2002.10.01
Abstract
Synthetic vectors have been considered as a safer and more versatile alternative to viral-based gene delivery systems. A variety of simple synthetic vector systems such as cationic lipid- and polymer-complexed plasmid DNA were shown to have a significant transfection activity in vitro but their use in vivo has been hampered by the decrease in transfection efficiency mediated by non-specific electrostatic interactions with serum components. (omitted)
Keywords