Enhanced Paclitaxel Bioavailability after Oral Administration of Paclitaxel Coadministered with Quercetin in Rats.

  • Published : 2002.10.01

Abstract

The purpose of this study was to investigate the effect of quercetin on the bioavailability of paclitaxel orally coadministered in rats Paclitaxel is reported to be metabolized by cytochrome p-450(CYP3.A,)in both the liver and epithelial cells of small intestine and also absorption of paclitaxel is inhibited by p-glycoprotein efflux Pump in the intestinal mucosa. This resulted in poor orall bioavailability of paclitaxel. Area under the plasma concentration-time curve (AUC) of paclitaxel in combination with quercetin were significantly (p< 0.01) higher than those of control. (omitted)

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