Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2002.10a
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- Pages.399.3-399.3
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- 2002
Dissolution Test for Indomethacin by the Portable Near-Infrared(NIR) System
- Kim, Do-Hyung (College of Pharmacy. Dongduk Women′s University) ;
- Lim, Hun-Rang (College of Pharmacy. Dongduk Women′s University) ;
- Chang, Soo-Hyun (College of Pharmacy. Dongduk Women′s University) ;
- Woo, Young-Ah (College of Pharmacy. Dongduk Women′s University) ;
- Kim, Hyo-Jin (College of Pharmacy. Dongduk Women′s University)
- Published : 2002.10.01
Abstract
Near-infrared (NIR) system was used to determine rapidly and simply indomethacin in buffer solution for a dissolution test for tablets and capsules. Indomethacin standards were prepared ranging from 10 to 50ppm using mixture of phosphate buffer(pH 7,2) and water(1:4), The near infrared(NIR) transmittance spectra of indomethacin standard solutions were collected by using a quartz cell in 1 mm and 2mm pathlength, Partial least-square regression (PLSR) was explored to develop calibration models over the spectral range 1100-1700nm. (omitted)
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