Development of economic preparative method of (S)-(+)-enantiomer of arylpropionic acids

  • Lee, Jae (College of Pharmacy Kangwon National University) ;
  • Shin, Dae (College of Pharmacy Kangwon National University) ;
  • Seo, Sang (Yuhan Coporatio) ;
  • Kang, Jong-Seong (ChungNam National University) ;
  • Kim, Kyeong (College of Pharmacy Kangwon National University)
  • 발행 : 2002.10.01

초록

Many of the chiral NSAIDs are marketed as racemates. There is an increasing interest in developing the enantiomerically pure forms of the NSAIDs because the anti-inflammatory activity of NSAIDs have previously been shown to be largely sterospecific for the (S)-(+)-enantiomer. Therefore, simple and economic preparative method to identify the (S)-(+)-enantiomer of NSAIDs (aryl propionic acids) as diastereomeric solvation complex was developed using several chiral solvating agents by recrystallization of racemate and solvent fractionation. (omitted)

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