대한약학회:학술대회논문집 (Proceedings of the PSK Conference)

대한약학회 (The Pharmaceutical Society of Korea)
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Tyrosinase and melanin biosynthesis inhibitory activities of crude drugs

  • Jun, Jung-Yang (MRRC and College of Pharmacy, Wonkwang University) ;
  • Ko, Eun-Kyung (MRRC and college of Pharmacy, Wonkwang University) ;
  • Kim, Mi-Hee (MRRC and college of Pharmacy, Wonkwang University) ;
  • Li-Xun (MRRC and College of Pharmacy, Wonkwang University) ;
  • Park, Sung-Uk (MRRC and College of Pharmacy, Wonkwang University) ;
  • Kim, Youn-Chul (MRRC and College of Pharmacy, Wonkwang University)
  • 발행 : 2002.10.01
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초록

Melanin biosynthesis inhibitors are useful not only for the materials used in cosmetics as skin-whitening agents but also for the remedy of hyperpigmentation. In order to find the new skin-whitening compounds from the natural products. screening of tyrosinase and melanin biosynthesis inhibitory activities in vitro has been carried out. The MeOH extracts and/or fractions of Polygoni multiflori Radix, Dalbergiae odoriferae Lignum. Solnani nigri Herba. Polygoni cuspidati Radix. POlygoni multiflori Ramulus. Salviae Radix showed tyrosinase inhibitory effects. Four methanolic extracts also showed melanin biosynthesis inhibitory effects in B-16 melanoma cell line.

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