대한약학회:학술대회논문집 (Proceedings of the PSK Conference)
- 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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- Pages.382.1-382.1
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- 2002
Screening of monocyte chemoattractant protein-1-induced chemotaxis inhibitors from medicinal herbs
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Lee, Seung-Woong
(Laboratory of Lipid Metabolism Korea Research Institute of Bioscience and Biotechnology)
;
- Kwon, Oh-Eok (College of Pharmacy, Chungnam National University) ;
- Lee, Jeong-Hyun (College of Pharmacy, Chungnam National University) ;
- Kim, Young-Ho (College of Pharmacy, Chungnam National University) ;
- Rho, Mun-Chual (College of Pharmacy, Chungnam National University) ;
- Lee, Hyun-Sun (College of Pharmacy, Chungnam National University) ;
- Kim, Young-Kook (College of Pharmacy, Chungnam National University)
- 발행 : 2002.10.01
초록
Blood monocytes are the precursors for the lipid-laden foam cells of early atherosclerotic lesions. Monocyte chemoattractant protein-1 (MCP-1), a CC chemokine. and chemokine receptor 2 (CCR2) playa crucial role in the recruitment of monocytes to the vascular lesion. Using the human monocyte THP-1 cell line. we investigated the inhibitory effects of methanol extracts of 127 medicinal herbs on MCP-1-induced chemotaxis. (omitted)
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