Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2002.10a
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- Pages.364.2-364.2
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- 2002
Asymmetric Synthesis of 12(S)-HETE
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Suh, Young-Ger
(College of Pharmacy, Seoul National University) ;
- Kim, Jin-Kwan (College of Pharmacy, Seoul National University) ;
- Min, Kyung-Hoon (College of Pharmacy, Seoul National University) ;
- Seo, Seung-Yong (College of Pharmacy, Seoul National University) ;
- Lee, Bo-Young (College of Pharmacy, Seoul National University) ;
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Han, Young-Taek
(College of Pharmacy, Seoul National University)
- Published : 2002.10.01
Abstract
(S) and (R) 12-HETE. endogenous eicosanoids. have recently been discovered to be implicated in a number of important biological activities. In particular. it has recently been reported by us that both the capsaicin-activated channel of sensory neurons and the cloned capsaicin receptor (VR1) are activated by the eicosanoids including these metabolites. We report herein a novel and efficient asymmetric synthesis of highly enantiomerically enriched 12(S)-HETE via enzymatic kinetic resolution of the key allylic alcohol synthon. (omitted)
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