Cleavage of Benzyl and p-Methoxybenzyl Ethers Using Chlorosulfonyl Isocyanate Reaction

Deprotection of the benzyl group has been widely used in multi-step organic synthesis with a variety of reaction conditions. including catalytic hydrogenolysis. Lewis acids such as FeCl$_3$ or MgBr$_2$ and lithium naphthalenide. However. these procedures sometimes can be problematic with multifunctional substrates. such as unsaturated bonds during hydrogenolysis. an acid-labile moiety in FeCl$_3$ and a easily reducible functional group in lithium naphthalenide. (omitted)