대한약학회:학술대회논문집 (Proceedings of the PSK Conference)
- 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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- Pages.349.1-349.1
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- 2002
Acyclic Vanilloid Receptor Antagonist Based on Capsazepine
- Park, Hyeung-Geun (Seoul National University) ;
- Park, Mi-Kyoung (Seoul National University) ;
- Choi, Ji-Yeon (Seoul National University) ;
- Choi, Se-Hoon (Seoul National University) ;
- Lee, Ji-Hye (Seoul National University) ;
- Suh, Young-Ger (Seoul National University) ;
- Oh, Uh-Taek (Seoul National University) ;
- Kim, Hee-Doo (Sookmyung Women′s University) ;
- Lee, Jee-Woo (Seoul National University) ;
- Park, Young-Ho (AmorePacific R & D Center) ;
- Jeong, Yeon-Su (AmorePacific R & D Center) ;
- Choi, Jin-Kyu (AmorePacific R & D Center) ;
- Jew, Sang-Sup (AmorePacific R & D Center)
- 발행 : 2002.10.01
초록
Capsaicin. the pungent component of chili pepper. opens a novel cation selective ion channel in the plasma membrane of peripheral sensory neurons. Capsaicin channel agonists induce pain upon topical application in the early stage. which is followed by a period of desensitization. Although the agonists have been studied as a analgesics, their initial irritancy became sever side effect. So competive antagonists have been pursued as a novel pharmacological agent for analgesics, rather than agonists. (omitted)
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