Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
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Synthesis and hypoglycemic Activity of the Substituted Pyrrolidine Thiazolidinedione Derivatives

  • Kim, Bok-Young (New Drug Research Laboratories, CKD Research Institute) ;
  • Ahn, Joong-Bok (New Drug Research Laboratories, CKD Research Institut) ;
  • Lee, Hong-Woo (New Drug Research Laboratories, CKD Research Institut) ;
  • Shin, Jae-Soo (New Drug Research Laboratories, CKD Research Institut) ;
  • Moon, Kyoung-Sik (New Drug Research Laboratories, CKD Research Institut) ;
  • Kim, Joon-Kyum (New Drug Research Laboratories, CKD Research Institut) ;
  • Lee, Do-Young (New Drug Research Laboratories, CKD Research Institut) ;
  • Ahn, Soon-Kil (New Drug Research Laboratories, CKD Research Institut) ;
  • Hong, Chung-Il (New Drug Research Laboratories, CKD Research Institute)
  • Published : 2002.10.01
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Abstract

Non-insulin dependent diabetes mellitus (NIDDM) is characterized by hyperglycemia, hyperinsulinemia. and impaired insulin action. Insulin resistance is considered to be the underlying mechanism in the pathogenesis of type 2 diabetes. which also leads to dyslipidemia, hypertension. and obesity. Thazolidinediones are a class of oral insulin-sensitizing agents that improve glucose utilization without increasing insulin release. They significantly reduce glucose, lipid and insulin levels in rodent models of NIDDM and obesity, and recent clinical data support theri efficacy in obese diabetic patients. (omitted)

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