Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2002.10a
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- Pages.336.1-336.1
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- 2002
Mn$2^+$ dependent ClpL ATPase in Streptococcus pneumoniae
- Park, Moo-Hyun (College of Pharmacy. Sungkyunkwan University) ;
- Kwon, Hyog-Young (College of Pharmacy. Sungkyunkwan University) ;
- Jung, Seung-Ha (College of Pharmacy. Sungkyunkwan University) ;
- Pyo, Suhk-Neung (College of Pharmacy. Sungkyunkwan University) ;
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Rhee, Dong-Kwon
(College of Pharmacy. Sungkyunkwan University)
- Published : 2002.10.01
Abstract
HSP100/Clp family functions as molecular chaperone and ATP dependent protease. The Streptococcus pneumoniae ClpL. a homologue of bacterial ClpB and yeast cytosolic HSP 104. is one of major heat shock proteins but its biochemical properties are unknown. In this study. ClpL in Streptococcus pneumoniaewas characterized using histidine tagged recombinant ClpL. When ATP hydrolysis activity was compared in the presence or absence of a variety of nucleotides or divalent ions. either ATP or Mn
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