Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2002.10a
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- Pages.336.2-336.2
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- 2002
Vitamin K Antagonist, NQ12 Inhibits PDGF-BB-Induced MAP Kinases Activation in Rat Aortic Vascular Smooth Muscle Cells
- Jeon, Jin-Seon (College of Pharmacy. Chungbuk National University) ;
- Pyo, Hyung-Bea (College of Pharmacy. Chungbuk National University) ;
- Kim, Jin-Ho (College of Pharmacy. Chungbuk National University) ;
- Kim, Soo-Yeon (College of Pharmacy. Chungbuk National University) ;
- Yoo, Hwan-Soo (College of Pharmacy. Chungbuk National University) ;
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Yun , Yeo-Pyo
(College of Pharmacy. Chungbuk National University)
- Published : 2002.10.01
Abstract
Several 1 A-naphthoquinone derivatives have been reported to possess many pharmacological effects such as anti-viral. anti-fungal. anti-cancer and anti-platelet activities. We have reported that 2-chloro-3-［4-(ethyICarbOxy)-phenyl］-amino-1.4-naphthoquinone(NQ12) had a potent inhibitory effect on the platelet aggregation in vitro and thrombosis in vivo. However. little has been known about functional roleot NQ12 on vascular smooth muscle cells (VSMCs). (omitted)
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