Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
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Transforming Growth Factor-${\beta}$ (TGF-${\beta}$) Induces Invasion and Migration of Ras- Transformed MCF10A Human Breast Epithelial Cells

  • Kim, Mi-Sung (College of Pharmacy. Duksung Women′s University) ;
  • Moon , A-Ree (College of Pharmacy. Duksung Women′s University)
  • Published : 2002.10.01
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Abstract

Transforming growth factor-${\beta}$ (TGF-${\beta}$), a hormonally active polypeptide found in normal and transformed tissues. regulates cellular growth and phenotyphic plasticity. We have previously shown that H-ras. but not N-ras. induces invasive phenotype in MCF10A human breast epithelial cells. In this study. we wished to examine the effect of TGF-${\beta}$ on H-ras-induced invasion and motility in MCFI 10A cells by performing in vitro invasion assay and wound migration assay. (omitted)

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