Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2002.10a
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- Pages.323.3-324
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- 2002
Apicidin Induction of cyclin E might be mediated by Spl Transcription Factor
- Kim, So-Young (Lab of Biochemistry ＆ Mol. Boilogy, College of Pharmacy, Department of Genetic Engineering College of Life sci. ＆ Tech. Sungkyungkwan University.) ;
- Cho, Eun-Jung (College of Medicine, Konyang University) ;
- Lee, Hoi-Young (College of Medicine, Konyang University) ;
- Hong , Sung-Youl (College of Medicine, Konyang University) ;
- Lee, Hyang-Woo (College of Medicine, Konyang University) ;
- Han, Jeung-Whan (College of Medicine, Konyang University)
- Published : 2002.10.01
Abstract
Histone deacetylases (HDAC) activity is associated generally with transcriptional repression. We have reported previously that apicidin. a histione deacetylase inhibitor. inhibited the proliferation of tumor cells via induction of p21 WAF/C1P1. We extended our study to identify the effect of apicidin on the expression of other cell cycle regulatory protein. such as cyclin E. a critical regulator of the transition from G1 into S phase. (omitted)
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