대한약학회:학술대회논문집 (Proceedings of the PSK Conference)
- 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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- Pages.317.1-317.1
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- 2002
An investigation of the effect of epigallocathechin-3-gallate on the renal dipeptidase release
- Kim, Yu-Jin (Department of Pharmacy, College of Pharmacy, Chonnam National University) ;
- Park, Eun-Mi (Department of Pharmacy, College of Pharmacy, Chonnam National University) ;
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Yoon, Hyun-Joong
(Department of Pharmacy, College of Pharmacy, Chonnam National University)
;
- Park, Haeng-Soon (Department of Pharmacy, College of Pharmacy, Chonnam National University)
- 발행 : 2002.10.01
초록
The action of epigallocatechin-3-gi:lllale (EGCG). polyphenol compound from green lea, on the release pattern of glycosylphosphatidylinositol (GPI)-anchored renal dipeptidase (RDPase) from renal proximal tubules (PTs) was examined. EGCG had a stronger inhibitory effect on the release of RDPase than alkaline phosphatase (APase), another GPI-anchored ectoenzyme used as a reference protein. The effect of EGCG on cell viability as assessed by MTT test was found to be intact, and moreover, was indicative of potent cell activation or proliferation. (omitted)
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