Binding modes of artemisinin to malarial TCTP demonstrated by computer modeling

The translationally controlled tumor-associated proteins (TCTPs) are a highly conserved and abundantly expressed family of eukaryotic proteins that are implicated in both cell growth and human acute allergic response but whose intracellular biochemical function has remained elusive. There are reports that antimalarial drug, artemisinin. binds to Plasmodium falciparum TCTP. however, its 3D structure has not been known. (omitted)