대한약학회:학술대회논문집 (Proceedings of the PSK Conference)

대한약학회 (The Pharmaceutical Society of Korea)
권호 표지

Cholinergic involvement of spatial memory impairment in $\mu$-opioid receptor knockout mice

  • Yoo, Ji-Hoon (Department of Pharmacology, College of Pharmacy, Sungkyunkwan University, Suwon) ;
  • Yang, Eun-Mi (Department of Pharmacology, College of Pharmacy, Sungkyunkwan University, Suwon) ;
  • Kim, Kyung-In (Department of Pharmacology, College of Pharmacy, Sungkyunkwan University, Suwon) ;
  • Lee, Seok-Yong (Department of Pharmacology, College of Pharmacy, Sungkyunkwan University, Suwon) ;
  • Jang, Choon-Gon (Department of Pharmacology, College of Pharmacy, Sungkyunkwan University, Suwon)
  • 발행 : 2002.10.01
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초록

The present study investigated the passive avoidance and spatial learning in the ${\mu}$-opioid receptor gene knockout mice and wild type mice. In the step-through passive avoidance task. the ${\mu}$-opioid receptor knockout mice did not differ from the wild type mice. In Morris water maze. however. the ${\mu}$-opioid receptor knockout mice showed significant memory deficit compared to wild type mice. (omitted)

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