대한약학회:학술대회논문집 (Proceedings of the PSK Conference)
- 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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- Pages.304.2-304.2
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- 2002
Erk activation mediates lipoPolysaccharide-induced induction of matrix metalloprotease-9 from rat primary astrocytes
- Lee, Woo-Jong (Department of Pharmacology, College of Pharmacy, Seoul National University) ;
- Yoo, Byung-Kwon (Department of Pharmacology, College of Pharmacy, Seoul National University) ;
- Park, Gyu-Hwan (Department of Pharmacology, College of Pharmacy, Seoul National University) ;
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Ko, Kwang-Ho
(Department of Pharmacology, College of Pharmacy, Seoul National University)
- 발행 : 2002.10.01
초록
In central nervous system. matrix metalloproteinases (MMPs) are produced by neuron as well as glia and implicated in physiological events such as neurite outgrowth and myelination etc. In addition. MMPs also contribute to the pathogenesis of several CNS diseases such as multiple sclerosis, Alzheimer's disease and malignant glioma. In spite of their functional importance, little is known about the signal transduction pathways leading to the induction of MMPs in CNS. Here. we investigated whether the activation of Erk(1/2) is involved in the induction of MMP-9 in LPS-stimulated primary astrocytes. (omitted)
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