대한약학회:학술대회논문집 (Proceedings of the PSK Conference)
- 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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- Pages.301.3-302
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- 2002
Kupffer Cells Are Responsible for Producing Hepatic Microsomal Drug Metabolizing Dysfunction during Trauma and Sepsis
- Lee, Sang-Ho (College of Pharmacy, Sungkyunkwan University) ;
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Kim, Joo-Young
(College of Pharmacy, Sungkyunkwan University) ;
- Kim, Sung-Ho (College of Pharmacy, Sungkyunkwan University) ;
- Eum, Hyun-Ae (College of Pharmacy, Sungkyunkwan University) ;
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Lee, Sun-Mee
(College of Pharmacy, Sungkyunkwan University)
- 발행 : 2002.10.01
초록
Sepsis remains the leading cause of morbidity and mortality following trauma. Although hepatocellular dysfunction occurs during trauma and sepsis. the mechanism responsible for this remains unclear. We investigated the role of Kupffer cells in the alterations in microsomal drug metabolizing function during trauma and sepsis. Rats were subjected to trauma by femur fracture (FFx). After 72h, polymicrobial sepsis was induced by cecal ligation and puncture(CLP). (omitted)
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