Effect of Trolox C on CYP450 Isozymes Activity and Expression in Hepatic Ischemia/Reperfusion

  • Eum, Hyun-Ae (College of Pharmacy. Sungkyunkwan University) ;
  • Kim, Sung-Ho (College of Pharmacy. Sungkyunkwan University) ;
  • Lee, Sun-Mee (College of Pharmacy. Sungkyunkwan University)
  • 발행 : 2002.10.01

초록

The present study was done to determine the effect of trolox C. a hydrophilic analogue of vitamin E. on alteration in cytochrome P-450 (CYP)-dependent drug metabolism during ischemia and reperfusion. Rats were subjected to 60 min of hepatic ischemia and 5 h of reperfusion. Rats were treated intravenously with trolox C (2.5 mg/kg) or vehicle (PBS. pH 7.4), 5 min before reperfusion. Serum alanine aminotransferase and lipid peroxidation levels were markedly increased after ischemia and reperfusion. This increase was significantly suppressed by trolox C. (omitted)

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