Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2002.10a
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- Pages.297.2-297.2
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- 2002
Effects of Protein Kinase Inhibitors on Histamine Release and ROS Generation in RBL 2H3 Cells
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Yoon, Mi-Yun
(College of Pharmacy, Chung-Ang University) ;
- Cho, Nam-Young (College of Pharmacy, Chung-Ang University) ;
- Lee, Ji-Yun (College of Pharmacy, Chung-Ang University) ;
- Seo, Moo-Hyun (College of Pharmacy, Chung-Ang University) ;
- Kim, Chang-Jong (College of Pharmacy, Chung-Ang University) ;
- Sim, Sang-Soo (College of Pharmacy, Chung-Ang University)
- Published : 2002.10.01
Abstract
Previous report showed that histamine release by HCI was mediated via reactive oxygen species (ROS) generation in RBL 2H3 cells. To investigate action of protein kinase on histamine release and ROS generation. we observed effects of protein kinase inhibitors on histamine release and ROS generation in RBL 2H3 cells stimulated by HCI HCI dose-dependently increased both histamine release and ROS generation. HCI-induced histamine release was significantly inhibited by bisindolmaleimide (10
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