Estrogenic Activities of Pyrethroid Compounds in MCF-7 BUS cells

  • Han, Soon-Young (Endocrine Toxicology Division, National Institute of Toxicological Research, Korea FDA) ;
  • Shin, Hae-Ho (Department of Pharmacy, Duksung Woman′s University) ;
  • Kang, Il-Hyun (Department of Pharmacy, Duksung Woman′s University) ;
  • Kim, In-Young (Department of Pharmacy, Duksung Woman′s University) ;
  • Kim, Hyung-Sik (Department of Pharmacy, Duksung Woman′s University) ;
  • Lee, Su-Jung (Department of Pharmacy, Duksung Woman′s University) ;
  • Moon, Hyun-Ju (Department of Pharmacy, Duksung Woman′s University) ;
  • Kim, Tae-Sung (Department of Pharmacy, Duksung Woman′s University) ;
  • Moon, A-Ree (Department of Pharmacy, Duksung Woman′s University) ;
  • Choi, Kwang-Sik (Department of Pharmacy, Duksung Woman′s University)
  • Published : 2002.10.01

Abstract

Pyrethroids are extensively used as insecticide in agriculture and home. Several studies have reported that yrethroids are relatively safe to humans and wildlife. However. some studies have suggested that pyrethroids ossess estrogen-like activity. Thus. the purpose of this study was to investigate the effects of pyrethroid ompounds on cell proliferation. and expression of ERs and pS2 using estrogen receptor positive human breast ancer cell line (MCF-7 BUS celis). (omitted)

Keywords