Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
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Identification of a 68 kDa cytosolic. neutral and Mg2＋-independent Sphingomyelinase by MALDI- TOF Analysis

  • Seo, Young-Deog (Department of Environmental and Health Chemistry, College of Pharmacy, Chung-Ang University, Seoul Korea) ;
  • Park, Hong-Jun (Department of Environmental and Health Chemistry, College of Pharmacy, Chung-Ang University, Seoul Korea) ;
  • Hyun, Myung-Han (Department of Environmental and Health Chemistry, College of Pharmacy, Chung-Ang University, Seoul Korea) ;
  • Cho, Dong-Hwan (Department of Environmental and Health Chemistry, College of Pharmacy, Chung-Ang University, Seoul Korea) ;
  • Jung, Sung-Yun (Department of Environmental and Health Chemistry, College of Pharmacy, Chung-Ang University, Seoul Korea) ;
  • Kim, Dae-Kyong (Department of Environmental and Health Chemistry, College of Pharmacy, Chung-Ang University, Seoul Korea)
  • Published : 2002.10.01
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Abstract

A cytosolic. neutral and magnesium-independent Sphingomyelinase (N-cSMase) is known to playa role in vitamin D3-induced differentiation and neurodegeneration such as Alzheimer's disease and stroke through the production of ceramide. a lipid-derived tumor suppressive mediator. However. little is known about its identity and characteristics. (omitted)

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