Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

The flavonoid quercetin inhibits dimethylnitrosamine-induced hepatic fibrosis in rats

  • Moon JeunOk (College of Pharmacy, Pusan National University) ;
  • Lee EunSil (College of Pharmacy, Pusan National University) ;
  • Lee HyeEun (College of Pharmacy, Pusan National University) ;
  • Lee MiHye (College of Pharmacy, Pusan National University) ;
  • Shin MiOk (College of Pharmacy, Pusan National University) ;
  • Shin JiYoung (Department of Anatomy College of Medicine, Pusan National University) ;
  • Youn Sik (Department of Anatomy College of Medicine, Pusan National University)
  • Published : 2002.10.01
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Abstract

Quercetin, one of the most abundant flavonoids in human diet has been reported to exhibit a wide range of pharmacological properties. In this study, we investigated the protective effect of quercetin on hepatic fibrosis induced by dimethylnitrosamine (DMN) in rats. Treatment with DMN caused a significant decrease in body and liver weight. Oral administration of quercetin (10 mg/kg daily for 4 weeks) remarkably prevented this DMN-induced loss in body and liver weight and inhibited the elevation of serum alanine transaminase. aspartate transaminase, and bilirubin levels. (omitted)

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