Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Sphingosine-1-Phosphate Decreases Melanin Synthesis via Sustained ERK Activation and Subsequent MITF Degradation

  • Kim, Dong-Seok (Department of Dermatology, Seoul National University College of Medicine) ;
  • Hwang, Eui-Soo (Department of Dermatology, Seoul National University College of Medicine) ;
  • Kim, Sook-Young (Department of Dermatology, Seoul National University College of Medicine) ;
  • Kwon, Sun-Bang (Department of Dermatology, Seoul National University College of Medicine) ;
  • Lee, Jai-Eun (Department of Dermatology, Seoul National University College of Medicine) ;
  • Sohn, Uy-Dong (Department of Pharmacology, College of Pharmacy, Chung Ang University) ;
  • Park, Kyoung-Chan (Department of Dermatology, Seoul National University College of Medicine)
  • Published : 2002.10.01
Download PDF
⟨ Previous Next ⟩

Abstract

This study shows that sphingosine-1-phosphate (SPP) significantly inhibits melanin synthesis in a concentration-dependent manner, and that the activity of tyrosinase was also reduced in SPP-treated cells. In contrast. a specific extracellular signal-regulated protein kinase (ERK) pathway inhibitor, PD98059 increased tyrosinase activity and melanin production, and PD98059 restored the reduced tyrosinase activity and pigmentation induced by SPP. (omitted)

Keywords