Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
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Sphingosine-1-phosphate Promotes the Survival of Mel-Ab Cells via ERK and Akt activation

  • Kim, Dong-Seok (Department of Dermatology, Seoul National University College of Medicine) ;
  • Hwang, Eui-Soo (Department of Dermatology, Seoul National University College of Medicine) ;
  • Kim, Sook-Young (Department of Dermatology, Seoul National University College of Medicine) ;
  • Lee, Jai-Eun (Department of Dermatology, Seoul National University College of Medicine) ;
  • Sohn, Uy-Dong (Department of Pharmacolgy, College of Pharmacy, Chung Ang University) ;
  • Park, Kyoung-Chan (Department of Dermatology, Seoul National University College of Medicine)
  • Published : 2002.10.01
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Abstract

Sphingolipids have been emerged as bioactive lipid modulators that mediate a variety of cell functions. However. the effects of sphingolipids on the cell growth and survival of melanocytes are not yet known. In the present study, we investigated the actions of sphingolipids in Mel-Ab melanocytes. We observed the cytoprotective effect of sphingosine-1-phosphate (SPP) on UVB-induced cell death. (omitted)

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