Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2002.10a
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- Pages.253.2-253.2
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- 2002
Synthesis and Evaluation of Biological activities of New Imine Derivatives of Apicidin
- Jin, Cheng-Hua (College of Pharmacy, Sungkyunkwan University) ;
- Kim, Hyung-Kyo (College of Pharmacy, Sungkyunkwan University) ;
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Han, Jeong-Whan
(College of Pharmacy, Sungkyunkwan University)
;
- Lee, Hyang-Woo (College of Pharmacy, Sungkyunkwan University) ;
- Lee, Yin-Won (College of Pharmacy, Sungkyunkwan University) ;
- Zee, Ok-Pyo (College of Pharmacy, Sungkyunkwan University) ;
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Jung, Young-Hoon
(College of Pharmacy, Sungkyunkwan University)
- Published : 2002.10.01
Abstract
Apicidin. a natural product HDAC inhibitor. is recently isolated from Fusarium sp. at Merk Research Laboratories, induces therapeutic applications as a broad spectrum antiprotozoal agent to muti-drug resistant malaria and a potential antitumor agent. The biological activity of apicidin appears to be apicocomplexan HDAC at low nanomolar concentrations. (omitted)
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