Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
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IN VIVO METABOLISM OF 2-METHYLAMINOETHYL-4,4'-DIMETHOXY-5,6,5',6'-DIMETHYLENEDIOXYBIPHENYL-2'-CARBOXY-2-CARBOXYLATE (DDB-S) BY LC/ESI TANDEM MASS SPECTROMETRY

  • Son, Jung-Hyun (Bioanalysis and Biotransformation Research Center, Korea Institute of Science and Technology) ;
  • Lee, Jae-Ick (Department of Biotechnology, Yonsei University) ;
  • Yang, Ryung (Bioanalysis and Biotransformation Research Center, Korea Institute of Science and Technology) ;
  • Kim, Dong-Hyun (Bioanalysis and Biotransformation Research Center, Korea Institute of Science and Technology)
  • Published : 2002.10.01
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Abstract

2-Methylaminoethyl- 4,4' -dimethoxy- 5, 5',6,6' -dimethylenedioxybiphenyl- 2' -carboxy- 2-carboxylate (DDB-S) is a synthetic compound derived from DDB. which is protects liver against carbon tetrachloride-, D-galactosamine-, thioacetamine-, and prednisolone- induced hepatic injury in experimental animals. We assessed the use of liquid chromatography/electrospray iontrap tandem mass spectrometry (LC/MS/MS) method to identify and quantify in vivo metabolites and to measure excretion. (omitted)

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