한국생물물리학회:학술대회논문집 (Proceedings of the Korean Biophysical Society Conference)

한국생물물리학회 (The Korean Biophysical Society)
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Extracellular Zinc Modulates Cloned T-type Calcium Channels

  • Lee, Jung-Ha (Department of Life Science, Sogang University) ;
  • Park, Byong-Gon (Department of Physiology and Institute of Basic Medical Science, Yonsei University Wonju College of Medicin) ;
  • Park, Jin-Yong (Department of Life Science, Sogang University) ;
  • Lee, Joong-Woo (Department of Physiology and Institute of Basic Medical Science, Yonsei University Wonju College of Medicin) ;
  • Jeong, Seong-Woo (Department of Physiology and Institute of Basic Medical Science, Yonsei University Wonju College of Medicine)
  • 발행 : 2002.06.01
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초록

In the present study, we investigated effects of extracellular zinc (Zn$\^$2＋/) on T-type Ca$\^$2＋/ channel isoforms (${\alpha}$lG, ${\alpha}$lH, and ${\alpha}$lI) stably expressed in HEK 293 cells. Ca$\^$2＋/ currents were measured using 10 mM Ca$\^$2＋/ as a charge carrier under whole cell-ruptured patch configuration. Zn$\^$2＋/ blocked the ${\alpha}$lH currents with a 100- and 200-fold higher potency (IC$\sub$50/ = 2.5 ${\mu}$M) when compared with those for blockade of the ${\alpha}$1G and ${\alpha}$1I currents, respectively.(omitted)

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