Proceedings of the Korean Biophysical Society Conference (한국생물물리학회:학술대회논문집)

The Korean Biophysical Society (한국생물물리학회)
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Increase of Cdk5 and p35 during Retinoic Acid-Induced Neuronal Differentiation of SK-N-BE(2)C cells

  • Lee, Jong-Hee (Department of Life Science, Pohang University of Science and Technology) ;
  • Kim, Kyung-Tai (Department of Life Science, Pohang University of Science and Technology)
  • Published : 2002.06.01
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Abstract

Cdk5, a neuronal Cdc2-like kinase, exhibits a variety of functions in neuronal differentiation and neurocytoskeleton dynamics as well as neuronal degeneration and cell death. However, its role in retinoic acid (RA)-induced differentiation has not been reported yet. We newly found that RA treatment of SK-N-BE(2)C, human neuroblastoma, increased expression of Cdk5 concomitantly with a neuronal specific activator, p35.(omitted)

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