Proceedings of the Korean Biophysical Society Conference (한국생물물리학회:학술대회논문집)

The Korean Biophysical Society (한국생물물리학회)
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Localization of Divalent Cation-Binding Site in the Pore of a Small Conductance $Ca^{2+}$-activated $K^+$ Channel and Its Role in Determining Current-Voltage Relationship

  • Heun Soh (Department of Life Science, Kwangju Institute of Science and Technology (K-JIST)) ;
  • Shin, Na-Rae (Department of Life Science, Kwangju Institute of Science and Technology (K-JIST) ;
  • Park, Chul-Seung (Department of Life Science, Kwangju Institute of Science and Technology (K-JIST))
  • Published : 2002.06.01
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Abstract

In our previous study (Soh and Park, 2001), we proposed that the inwardly rectifying current-voltage (I-V) relationship of small-conductance $Ca^{2＋}$-activated $K^{＋}$ channels (S $K_{Ca}$ channels) is the result of voltage-dependent blockade of $K^{＋}$ currents by intracellular divalent cations. We expressed a cloned S $K_{Ca}$ channel, rSK2, in Xenopus oocytes and further characterized the nature of the divalent cation-binding site by electrophysiological means.(omitted)

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