Proceedings of the Korean Biophysical Society Conference (한국생물물리학회:학술대회논문집)

The Korean Biophysical Society (한국생물물리학회)
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Permeation and Gating of Inward Rectifer Potassium Channels

  • Choe, Han (Department of Physiology, Ulsan University College of Medicine) ;
  • Palmer, Larry G. (Department of Physiology, Cornell University Weill Medical Colleg) ;
  • Sackin, Henry (Department of Physiology, Chicago Medical School)
  • Published : 2002.06.01
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Abstract

The gating kinetics of an inward-rectifier K$\^$＋/ channel, ROMK2 (Kir1.lb), were described by a model having one open state and two closed states. The long closed state was abolished by EDTA, suggesting that it was due to block by divalent cations. These closures exhibit a biphasic voltage-dependence, implying that the divalent blockers can permeate the channel.(omitted)

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