Structure of a Human Insulin Peptide-HLA-DQ8 Complex and Susceptibility to Type 1 Diabetes

  • Lee, Kon-Ho (Division of Applied Life Science, Plant Molecular Biology and Biotechnology Research Center, Gyeongsang National University)
  • Published : 2002.06.01

Abstract

The major histocompatibility complex (MHC) is an important susceptibility locus for many human autoimmune diseases. The structural and functional properties of HLA-DR molecules that are associated with susceptibility to several autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis, have been defined.(omitted)

Keywords