한국동물번식학회:학술대회논문집 (Proceedings of the KSAR Conference)
- 한국동물번식학회 2002년도 춘계학술발표대회 발표논문초록집
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- Pages.22-22
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- 2002
A Testicular Autoantigen Capable of Binding Igg Is Expressed by Undifferentiated Spermatogonial Stem Cells after Busulfan Treatment
- Lee Mi-Suk (Dept. of Dairy Science, Division of Applied Life Science, Gyeongsang National University) ;
- Gwon Deuk-Nam (Dept. of Dairy Science, Division of Applied Life Science, Gyeongsang National University) ;
- Park Chan-Gyu (Laboratory of Molecular Genetics, Department of Animal Biotechnology, Cheju National University) ;
- Kim Jin-Hoe (Dept. of Dairy Science, Division of Applied Life Science, Gyeongsang National University)
- 발행 : 2002.06.01
초록
Identification of spermatogonial stern cell-specific surface molecules is important in understanding the molecular mechanisms underlying the maintenance and differentiation of these cells. We have found that spermatogonia from busulfan treated mice expressed an autoantigen that distinguishes between undifferentiated and differentiated spermatogonia. Four to six weeks after busulfan treatment, germ cells located in the basal compartment of seminiferous epithelium show isotype-specific IgG deposits that form due to autoimmunity. (omitted)