Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)
- 2002.11b
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- Pages.149-150
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- 2002
THE REGULATION OF CYP1A1 GENE EXPRESSION BY ESTRADIOL AND ITS METABOLITES
- Joung, Ki-Eun (College of Pharmacy, Ewha Womans University) ;
- Sheen, Yhun-Yhong (College of Pharmacy, Ewha Womans University)
- Published : 2002.11.01
Abstract
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is the most potent halogenated aromatic hydrocarbon congener that induces expression of several genes including CYP1A. Exposure to TCDD results in many toxic actions such as carcinogenesis, hepatotoxicity, immune suppression, reproductive toxicity and developmental toxicity.(omitted)