THE REGULATION OF CYP1A1 GENE EXPRESSION BY ESTRADIOL AND ITS METABOLITES

  • Published : 2002.11.01

Abstract

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is the most potent halogenated aromatic hydrocarbon congener that induces expression of several genes including CYP1A. Exposure to TCDD results in many toxic actions such as carcinogenesis, hepatotoxicity, immune suppression, reproductive toxicity and developmental toxicity.(omitted)

Keywords