Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
권호 표지

Glucose Transport in Jurkat Cell: Concentration-Dependent Regulation

  • Koh, Woo-S. (Korea Institute of Toxicology) ;
  • Shin, Ki-D. (Korea Institute of Toxicology) ;
  • Lee, Jeong-W. (Korea Institute of Toxicology) ;
  • Chung, Moon-K. (Korea Institute of Toxicology) ;
  • Han, Sang-S. (Korea Institute of Toxicology)
  • Published : 2002.11.01
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Abstract

In this study, a mechanism by which glucose level modulates glucose transport in Jurkat cells was investigated. Glucose uptake was more efficient in the cells cultivated in low glucose (2.5 mM) medium than that grown in high glucose (20 $\mu$M) medium. Vmax (0.74 n㏖/10$^6$ cells$\cdot$min) of glucose uptake measured with the cells grown in the low glucose medium was higher than the one (1.06 n㏖/10$^6$ cells$\cdot$min) in the high glucose medium while Km was almost consistent through the change of glucose levels, indicating the increase of glucose transporter number.

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