한국독성학회:학술대회논문집 (Proceedings of the Korean Society of Toxicology Conference)
- 한국독성학회 2002년도 Molecular and Cellular Response to Toxic Substances
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- Pages.144-144
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- 2002
Potentiation of Lipopolysaccharide-Inducible COX-2 Expression by C2-ceramide: The Role of JNK- and AP-1-Mediated C/EBP$\beta$ Activation
- Cho, Yang-Hee (National Research Laboratory (MDT), College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University) ;
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Lee, Chang-Ho
(Department of Pharmacology and Institute of Biomedical Science (C.H.L.), College of Medicine, Hanyang University)
;
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Kim, Sang-Geon
(National Research Laboratory (MDT), College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University)
- 발행 : 2002.11.01
초록
Ceramide, formed by sphingomyelinase, is involved in the expression of cyclooxygenase-2 (COX-2). This study examines the effect of C2-ceramide (C2), a cell-permeable ceramide analog, on the LPS-inducible COX-2 expression and signaling pathways.(omitted)