Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)
- 2002.11b
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- Pages.144-144
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- 2002
Potentiation of Lipopolysaccharide-Inducible COX-2 Expression by C2-ceramide: The Role of JNK- and AP-1-Mediated C/EBP$\beta$ Activation
- Cho, Yang-Hee (National Research Laboratory (MDT), College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University) ;
- Lee, Chang-Ho (Department of Pharmacology and Institute of Biomedical Science (C.H.L.), College of Medicine, Hanyang University) ;
- Kim, Sang-Geon (National Research Laboratory (MDT), College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University)
- Published : 2002.11.01
Abstract
Ceramide, formed by sphingomyelinase, is involved in the expression of cyclooxygenase-2 (COX-2). This study examines the effect of C2-ceramide (C2), a cell-permeable ceramide analog, on the LPS-inducible COX-2 expression and signaling pathways.(omitted)