한국독성학회:학술대회논문집 (Proceedings of the Korean Society of Toxicology Conference)
- 한국독성학회 2002년도 Current Trends in Toxicological Sciences
- /
- Pages.114-114
- /
- 2002
COMPARISON OF EMETIC POTENTIAL INDUCED BY PDE IV INHIBITORS IN THE FERRET
- Park, Jae-Mook (R ＆ D center of Pharmaceuticals, CJ corporation) ;
- Lee, Sung-Hak (R ＆ D center of Pharmaceuticals, CJ corporation) ;
- Kim, Il-Hwan (R ＆ D center of Pharmaceuticals, CJ corporation) ;
- Yeon, Kyu-Jeong (R ＆ D center of Pharmaceuticals, CJ corporation) ;
- Kim, Dal-Hyun (R ＆ D center of Pharmaceuticals, CJ corporation)
- 발행 : 2002.05.01
초록
Inhibitors of type IV phosphodiesterase (PDE IV) are currently being developed as new therapeutic agents for asthma, chronic obstructive pulmonary disease(COPD) and arthritis. Unfortunately, the anti-inflammatory effect of PDE IV inhibitors has been considered to be associated to some extent with vomiting as adverse effect. The first generation PDE IV inhibitor, rolipram, was known to induce emesis at clinical trials. (omitted)