Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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ACTIVATION OF P38 MAP KINASE AND AP-1 DURING THE PROMOTION OF NEURITE EXTENSION OF PC-12 CELLS BY 15-DEOXY-$\Delta$12,14-PROSTAGLANDIN J2

  • Song, Y.S. (College of Pharmacy, Chungbuk National University) ;
  • Oh. J.H. (National Institute of Toxicological Research, KFDA) ;
  • Park, K.S. (National Institute of Toxicological Research, KFDA) ;
  • Jung, K.M. (National Institute of Toxicological Research, KFDA) ;
  • Lee, M.K. (College of Pharmacy, Chungbuk National University) ;
  • Jung, H.K. (National Institute of Toxicological Research, KFDA) ;
  • Jung, S.Y. (National Institute of Toxicological Research, KFDA) ;
  • Hong, J.T. (College of Pharmacy, Chungbuk National University)
  • Published : 2002.05.01
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Abstract

15-Deoxy-$\Delta$12, 14-prostaglandin J2 (15-deoxy-PGJ2), a naturally occurring ligand activates the peroxisome proliferator-activated receptor-$\gamma$(PPAR-$\gamma$). It was known to have promoting ability of nerve growth factor(NGF)-induced neurite extension. However, it is not clear yet as to what signaling pathway is involved in its promoting ability of neurite extension.(omitted)

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