Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)
- 2002.05a
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- Pages.103-104
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- 2002
CELECOXB (CELEBREX) INHIBITS PHORBOL ESTER-INDUCED COX-2 EXPRESSION AND $PGE_2$ PRODUCTION IN MOUSE SKIN: AP-1 AND C/EBP AS POSSIBLE MOLECULAR TARGETS
- Chun, Kyung-Soo (Seoul National University) ;
- Surh, Young-Joon (Seoul National University)
- Published : 2002.05.01
Abstract
Cyclooxygenase (COX), an important enzyme involved in mediating the inflammation, catalyzes the rate-limiting step in the formation of prostaglandins from arachidonic acid. There are two isoforms of COX, designated as COX-1 and COX-2. While COX-1 is constitutively expressed in most tissues, COX-2 can be induced transiently by proinflammatory cytokines, endotoxins, growth factors, oncogenes, UV and mitogens.(omitted)