Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)
- 2002.05a
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- Pages.96-96
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- 2002
ZEARALENONE INDUCES MALE GERM CELL APOPTOSIS IN RATS
- Kim, Il-Hwan (Korea Institute of Toxicology) ;
- Kim, Yong-Bum (Korea Institute of Toxicology) ;
- Son, Hwa-Young (Chungnam National University) ;
- Cho, Sung-Whan (Chungnam National University) ;
- Ha, Chang-Su (Korea Institute of Toxicology) ;
- Kang, Boo-Hyon (Korea Institute of Toxicology)
- Published : 2002.05.01
Abstract
Zearalenone (ZEA), a nonsteroidal estrogenic mycotoxin, is known to cause toxicity of testis in male rats. To investigate whether apoptosis is involved in ZEA-induced testicular toxicity and to identify the stage and target germ cell type, 10-weeks-old Sprague-Dawley male rats were treated with a single intraperitoneal (i.p.) dose of ZEA (5mg/kg) and euthanized at 3, 6, 12, 24, and 48 h subsequently.(omitted)