Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)
- 2002.05a
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- Pages.95-95
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- 2002
THE DNA TOPOISMERASE I INHIBITOR $\beta$ -LAPACHONE INHIBITS PROLIFERATION AND DOWNREGULATES CYCLOOXYGENASE-2 GENE EXPRESSION IN HUMAN PROSTATE CARCINOMA CELLS
- Kong, Kyu-Ri (Department of Biochemistry, Dong-Eui University College of Oriental Medicine and Research Center for Oriental Medicine) ;
- Park, Byung-Tae (Department of Anatomy, Dong-Eui University College of Oriental Medicine and Research Center for Oriental Medicine) ;
- Park, Yung-Hyun (Research Center for Oriental Medicine)
- Published : 2002.05.01
Abstract
Cyclooxygenases (COXs) are key enzymes in the conversion of arachidonic acid into prostanoids, which are involved in cell proliferation and inflammation. Two distinct COXS have been identified: COX-l which is constitutively expressed and COX-2 which is induced by different products such as tumor promoters or growth factors.(omitted)