THE DNA TOPOISMERASE I INHIBITOR $\beta$-LAPACHONE INHIBITS PROLIFERATION AND DOWNREGULATES CYCLOOXYGENASE-2 GENE EXPRESSION IN HUMAN PROSTATE CARCINOMA CELLS

  • Kong, Kyu-Ri (Department of Biochemistry, Dong-Eui University College of Oriental Medicine and Research Center for Oriental Medicine) ;
  • Park, Byung-Tae (Department of Anatomy, Dong-Eui University College of Oriental Medicine and Research Center for Oriental Medicine) ;
  • Park, Yung-Hyun (Research Center for Oriental Medicine)
  • Published : 2002.05.01

Abstract

Cyclooxygenases (COXs) are key enzymes in the conversion of arachidonic acid into prostanoids, which are involved in cell proliferation and inflammation. Two distinct COXS have been identified: COX-l which is constitutively expressed and COX-2 which is induced by different products such as tumor promoters or growth factors.(omitted)

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